Biotransformation Esketamine is extensively metabolised inside the liver. The principal metabolic pathway of esketamine in human liver microsomes is N-demethylation to type noresketamine. The main cytochrome P450 (CYP) enzymes responsible for esketamine N-demethylation are CYP2B6 and CYP3A4.Antibiotics can be a prescription medication and thus you … Read More